Conformationally restricted dynamic supramolecular catalysts for substrate-selective epoxidations.

Synthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine

Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...

Synthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine

Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...

Screening of a supramolecular catalyst library in the search for selective catalysts for the asymmetric hydrogenation of a difficult enamide substrate.

Metalloenzyme-mimicking supramolecular catalyst for highly active and selective intramolecular alkyne carboxylation.

Creation of synthetic catalysts with enzyme-like behavior is challenging despite strong interest in such systems. Extraction of tetrachloroaurate into the hydrophilic core of an interfacially cross-linked reverse micelle (ICRM) produced an artificial "metalloenzyme" with highly unusual catalytic properties. The ICRM pulled the substrate toward the catalytic metal, which converted it efficiently...

Synthesis and supramolecular properties of conformationally restricted and flexible phospholipids.

Short synthetic routes are described to produce structurally related phospholipids that are either conformationally restricted or flexible. The conformationally restricted structures have a cyclopropyl ring in the interfacial region of the phospholipid. The key synthetic step is a cyclopropanation reaction between 2(5H)-furanone and a stabilized chloroallylic phosphonate anion. The synthetic ro...